Please ensure Javascript is enabled for purposes of website accessibility

The Magnesium and Headache Connection

Do you suffer from tension-type or migraine headaches? If so, has your doctor recommended magnesium supplementation as a primary way to prevent yourheadaches? If not, you should be aware that many studies suggest a relationship between magnesium deficiency and mild to moderate tension and migraine headaches.

The Magnesium Factor

Magnesium is a mineral that acts as a powerhouse in the body. Magnesium is involved in more than 300 enzyme reactions that range from energy production to detoxification, bone formation to muscle contraction, DNA synthesis, to the formation of neurotransmitters and hormones. The body contains around 25 grams of magnesium, most contained in the bones and muscles. Since most magnesium is stored in the body, regular blood testing is not an accurate way to measure intracellular (inside the cell) levels.

Are You Deficient?

Research has shown that approximately 50% of people do not consume enough magnesium.

Many people become depleted in magnesium due to:

  • Medications (e.g., PPI drugs for GERD; diuretics for high blood pressure)
  • Depleted levels in crops
  • Refined foods
  • Overconsumption of alcohol and caffeine
  • Malabsorption conditions (Crohn's Disease)
  • Excess calcium supplementation
  • Diseases such as diabetes, kidney disease, liver disease
  • High levels of physical activity
  • High aluminum intake (cookware, medications, baking powder) depletes magnesium
  • Pregnancy
  • High stress

Research has shown that most Americans need an extra 300 mg of magnesium daily to prevent chronic diseases. Good food sources include pumpkin seeds, chia seeds, almonds, spinach, black beans, and brown rice.

Prevent Headaches With Magnesium

When one is deficient in magnesium, it leads to biochemical changes that can cause headaches. For example, magnesium prevents the overactivity of neurons (nerve cells), reduces inflammation signaling, and normalizes dilation of the arteries.

Several studies have been published examining magnesium supplementation and the prevention of migraines in adults and children. For example, one study of adult migraines found that 600 mg of magnesium supplementation reduced the frequency of migraine attacks by 41.6% compared to those receiving placebo which had a 15.8% improvement. A review of five randomized, double-blind, placebo-controlled trials for adult migraines found that 600 mg daily was well tolerated and effective.

The Right Dose

Depending on their diet and other risk factors, most patients supplement 400 mg to 600 mg daily of magnesium. There are different forms of supplemental magnesium available. I often recommend magnesium bisglycinate since it is well absorbed and less likely to cause digestive upset. It is important to know that too much magnesium can cause loose stool or diarrhea. If one has kidney disease, magnesium supplementation should only be used under a doctor's supervision.

Dr. Mark Stengler NMD, MS, is a bestselling author in private practice in Encinitas, California, at the Stengler Center for Integrative Medicine. His newsletter, Dr. Stengler’s Health Breakthroughs, is available at  www.markstengler.com and his product line at www.drstengler.com

References

DiNicolantonio JJ, O'Keefe JH, Wilson W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis [published correction appears in Open Heart. 2018 Apr 5;5(1):e000668corr1]. Open Heart. 2018;5(1):e000668. Published 2018 Jan 13. doi:10.1136/openhrt-2017-000668

Maier JA, Pickering G, Giacomoni E, Cazzaniga A, Pellegrino P. Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate. Nutrients. 2020;12(9):2660. Published 2020 Aug 31. doi:10.3390/nu12092660

Office of dietary supplements - magnesium. NIH Office of Dietary Supplements. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/. Accessed January 6, 2022.